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So I was scrolling through my phone and thought—why does crypto still feel like a second job? Wow. Mobile-first is where it’s at, though actually, the experience varies wildly between apps. Initially I thought all wallets were the same, but that first transfer to a new chain taught me otherwise, and it stung. Here’s the thing.
Whoa! This is about simple moves that make a difference. If you want to stake crypto or buy coins with a card without pulling your hair out, there are clear choices. My instinct said start small and learn through doing. On one hand convenience matters; on the other hand security matters even more.
Buying crypto with a card should be quick and secure. Seriously? Yes. The flow usually takes under five minutes on a good mobile wallet. But fees and KYC steps sneak in, and they can be confusing if you’re new. I’ll walk through practical steps and real tradeoffs—no fluff.
Mobile is the primary interface for most people in the US. Hmm… you pull out your phone more than your laptop. A good multi-chain wallet puts many networks and tokens in one place, avoiding constant app hopping. That convenience saves time and reduces mistakes, though it can also tempt risky behavior. My bias? I like tools that encourage deliberate decisions.
Here’s a concrete example. I wanted to stake small amounts across two chains. The process felt seamless with the right wallet, and it saved me from juggling multiple seed phrases. That part saved me time and a little anxiety. (Oh, and by the way, if you’re shopping wallets, check the link I mention below.)
Okay, so check this out—buying crypto with a debit or credit card is straightforward on most mobile wallets. Wow. First, confirm the app supports card purchases and the specific token you want. Then verify your identity if needed, which is normal for US users. Finally, authorize the card payment and wait for the funds to appear in your wallet.
Short recap: add card, complete KYC, buy, and secure. Seriously? Yes. Fees vary a lot between providers. Some platforms bundle network fees invisibly, while others show them upfront, and that matters when you’re buying small amounts. My rule of thumb is to expect at least 2-4% total cost on a simple card buy, though promos sometimes cut that.
Staking is, simply put, locking crypto to help secure a network and earn rewards. Whoa! Rewards rates differ by token and network. For newcomers, PoS staking is attractive because compounds can be meaningful over time. But staking also ties up liquidity and can require lockups or unbonding periods. I’m not 100% sure about every validator nuance for every chain, but you can learn the essentials quickly.
Here’s the practical checklist: choose a reliable validator, understand lockup timing, and check fees. Hmm… that sounds simple—because it is, mostly. Watch for slashing risks on some chains; though actually that’s rare for big validators, it’s not impossible. Diversify your stakes across validators when possible.
I’ll be honest—I’m biased toward wallets that balance ease and control. trust wallet has earned a place on my phone for that reason. It supports many chains, offers in-app purchases by card, and provides staking options for several tokens. My instinct said it was clunky at first, but updates smoothed the rough edges. If you want a single entry point for buying and staking on mobile, consider trust wallet.
Check the app’s native buy flow and staking UI before you commit. Seriously—test with a small amount first. That lets you learn the UI without risking much. Also look for clear transaction history and unbonding timelines in the staking tab.
Don’t skip seed phrase protection. Whoa! Write it down physically and store it securely. If you lose it, most wallets can’t help recover funds. Use a hardware wallet for large balances when you can. For day-to-day staking and small buys, mobile wallets are fine, but compartmentalize: keep a “spend” wallet and a “hold” wallet.
Enable biometrics and a strong pin. Hmm… sometimes that feels like overkill, though actually it reduces theft risk dramatically. Avoid storing photos of your seed phrase. Also double-check contract addresses when adding custom tokens—scammers love fake tokens. My tiny pet peeve: too many people import random tokens and then wonder why approval transactions drain gas.
Fees vary by chain. Wow. Ethereum fees can spike, while chains like BNB or Polygon tend to be cheaper. Card buys add processing fees and possible FX charges if you’re not using USD. Confirm the total cost before approving a purchase. For staking, some networks deduct a small commission from rewards.
Taxes are real in the US. Seriously. Buying crypto with a card is not a taxable event by itself, but selling or trading usually is. Earned staking rewards are typically taxable as income when received. Keep records. I use periodic snapshots of my transactions to simplify yearly reporting; it’s tedious, but worth it.
Here’s what bugs me about novice moves: they rush, ignore fees, and skip backups. Whoa! Rushing leads to wrong chain choices and lost funds. Double-check the token symbol and chain before buy. Use small test amounts for new flows. And don’t blindly accept token approvals—read the prompts.
Another common error is leaving all funds in a custodial on-ramp after buying. Move coins to a non-custodial wallet if you want control. Hmm… custodial convenience is real, but control comes with responsibility. If you stake large sums, consider using reputable validators and split stakes to lower risk.
Start with small buys via card for convenience. Wait for confirmation. Transfer a portion to a non-custodial mobile wallet and stake a small amount to learn the process. Whoa! Monitor unstaking times and rewards for a few cycles before increasing allocation. That approach teaches you the timing and fees without heavy exposure.
Then, if comfortable, scale gradually and consider hardware cold storage for long-term holdings. Hmm… that sounds conservative—because it is. I’m personally ok with small experimental amounts on mobile and critical holdings locked offline.
Yes, generally safe if you use reputable providers and confirm transactions. Keep in mind card fees and possible identity verification steps. Use small amounts for first-time purchases to verify the flow.
Absolutely. Many mobile wallets let you stake directly from the app. Check lockup and unbonding details before staking. Choose validators with good uptime and transparent commission structures.
If you’ve backed up your seed phrase, restore your wallet on another device. If you didn’t, funds are likely unrecoverable. That’s why seed security is the most critical step.
Alright—let me wrap this up a bit differently. At first I thought mobile crypto was all hype, but after doing the small experiments I saw real value. Something felt off about the complexity, though improvements keep coming. I’m optimistic but cautious. Try small, learn fast, and secure everything like it’s actually valuable—because it is.
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| Velocità di pagamento | Conferma istantanea o entro pochi minuti |
| Riduzione delle commissioni | Costi inferiori rispetto ai metodi tradizionali |
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NIDA is a biomedical research organization and does not provide personalized medical advice, treatment, counseling, or legal consultation. Find out more about NIDA-supported studies related to psilocybin. There is no data on the safety of taking psilocybin during pregnancy, for either a mother or a developing baby.
HIDTA seizures don’t encompass all drug seizures in the US; however, the researchers did observe similar overall increases by region based on data published by the DEA National Forensic Laboratory Information System. In addition, research suggests that psilocybin is the most consumed plant-based psychedelic drug in the United States, with 11.3% of individuals aged 12 or older in the United States reporting having ever used psilocybin in 2022. Self-reported data on the prevalence of their use is limited, though available research suggests that use of drugs like psilocybin that cause hallucinations has increased among adults aged in recent years. Though law enforcement seizures do not necessarily reflect prevalence of use, they represent an indicator of the availability of illicit drugs. Though there was a significant increase in the total weight of psilocybin mushrooms seized between 2017 and 2022 overall, the investigators found that the total weight seized peaked in 2021 (1,542 kg/3,400 lbs). In addition, the total weight of psilocybin mushrooms seized by law enforcement increased from 226 kg (498 lbs) seized in 2017 compared to 844 kg (1,861 lbs) in 2022.
However, the legal status of some of these drugs is evolving. Microdosing refers to regularly taking these drugs in very small amounts, typically one tenth to one twentieth of a typical non-clinical dose. Among people aged 12 or older in 2020, 0.2% (or about 493,000 people) had a hallucinogen use disorder in the past 12 months. To be diagnosed with a substance use disorder, a person must meet specific diagnostic criteria for continued substance use despite negative consequences. In a 1966 study where people with pre-existing psychoses were given LSD, three of 65 participants experienced persistent worsening of their psychiatric symptoms lasting 3-8 months.51
In modern psychedelic research, as a precaution, participants with previously diagnosed psychosis or bipolar Psilocybin Mushrooms disorder, and sometimes other mental illnesses, are excluded from participation. While dissociative drugs can alter perception, they also typically make people feel disconnected from their body and environment.6 These drugs can make people feel disconnected from their body and environment.6 Stigma can make individuals with substance use disorders less likely to seek treatment.
The FDA has also granted Breakthrough Therapy designation for two formulations of psilocybin being studied as potential medical treatments for depression. The U.S. Food and Drug Administration (FDA) has approved the ketamine derivative esketamine (under the brand name Spravato®) as a treatment for severe depression in patients who do not respond to other treatments.49 The FDA has also granted Breakthrough Therapy designation for two formulations of psilocybin being studied as potential medical treatments for depression. In religious ceremonies.24 References to psychedelic drug use have been found in ancient texts from India and Greece.2
The researchers found that most seizures occurred in the Midwest (36.0%), followed by the West (33.5%). NIH-supported research highlights need to better understand psilocybin in context of growing psychedelic use The institute also supports clinical investigations into psilocybin as a therapeutic substance. Though some people claim psilocybin has improved their symptoms, research to date has not established that microdosing is safe or effective.11
People may use them for their mind- and mood-altering effects, for recreation, or to have an emotional or spiritual experience. NIDA also funds research on how and why people use these substances. This basic research plays an important role in identifying their health effects and potential therapeutic uses.
For more information about NIH and its programs, visit NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. In addition, law enforcement efforts may vary across areas, and a higher number of seizures could be a result of increased vigilance by law enforcement. In recent years, possession of psilocybin has become increasingly decriminalized throughout the U.S. at the state level.
While many emerging and established substances are classified as psychedelic and dissociative drugs, NIDA-supported research mainly focuses on the following substances, which are more commonly used and/or are being investigated as potential medical treatments. NIDA supports and conducts research to learn whether some of these drugs may help treat substance use disorders in medical settings. Although research is ongoing, studies suggest psychedelic drugs—such as psilocybin, LSD, and DMT—primarily affect 5-HT2A receptors in the brain, which ordinarily are activated by the neurotransmitter (chemical messenger) serotonin.10 NIDA supports and conducts research on the short- and long-term health effects of psychedelic and dissociative drugs to better inform health decisions and policies related to their use. Researchers are also studying whether some of these substances may be effective treatments for mental health disorders, including addiction, when administered in a clinical setting.4,5
Some people who take psilocybin have extreme fear, anxiety, panic, or paranoia as they experience its hallucinogenic effects, which is known as a “bad trip.”17 People may also experience side effects like agitation, confusion, vomiting or nausea, which may be severe and require medical attention.14 With more public interest and, in some areas, fewer legal restrictions on psilocybin use, exposures reported to poison control centers have increased over the past few years.15 Psilocybin is part of a group of drugs called psychedelics—or hallucinogens—that have the potential to change a person’s sense of reality, leading them to see, hear, and feel things that are not happening in real life, or to experience reality in a different way.2 People report that they microdose to lessen mental health symptoms such as depression and stress, improve productivity, and ease pain. PCP can also cause psychosis that persists for days to weeks.6,54 While it is not clear whether ketamine raises the risk of long-term psychosis, people who engage in regular recreational use of ketamine are more likely to experience delusions, even after weeks of abstinence.55 Animal studies show that long-term use of PCP or ketamine can cause brain changes resembling those seen in people with schizophrenia.56
The data used for the analysis were collected through the High Intensity Drug Trafficking Areas (HIDTA) program, a grant program aimed at reducing drug trafficking and misuse administered by the Office of National Drug Control Policy. This analysis, published in Drug and Alcohol Dependence, was led by researchers at NYU Langone Health, New York City, and the University of Florida, Gainesville. The greatest total weight in seizures came from the West (1,864 kg/4,109 lbs, representing 42.6% of all seizures), followed by the South (1,832 kg/4,039 lbs, representing 41.8%). The number of law enforcement seizures increased from 402 seizures in 2017 to 1,396 in 2022. Information provided by NIDA is not a substitute for professional medical care or legal consultation.
Drugs that primarily affect how the brain processes the chemical glutamate. Drugs that primarily influence the way the brain processes the chemical serotonin. Using preferred language can help accurately report on substance use and addiction. They are also relapsing conditions, in which periods of abstinence (not using substances) can be followed by a return to use.
Dissociative drugs, including ketamine and PCP, block the action of N-methyl-D-aspartate (NMDA) receptors. For more information about NIDA and its programs, visit NIDA supports most of the world’s research on the health aspects of drug use and addiction. “We are in the middle of a rapidly evolving cultural, media, and legal landscape when it comes to psychedelics, and we need data to help shape informed and appropriate public health strategies,” said NIDA Director Nora D. Volkow, M.D.
The risk of mental health problems such as psychosis or suicidality in supervised clinical settings among people who participate in research on psilocybin is low. Learn more about psychedelic and dissociative drugs and their legal status in the United States from the DEA. Though most of these substances remain federally controlled, some states and the District of Columbia have decriminalized possession of psilocybin and some similar drugs (meaning there are no criminal penalties for possessing smaller amounts of the substance for personal use) or deprioritized enforcement of laws against the substances. Researchers are also interested in the psychedelic and dissociative properties of other drugs. While some debate remains on how to describe these drugs and how specific drugs are classified, researchers generally classify them according to how they work in the brain. Some organizations are using harm reduction practices to help avoid drug overdose deaths related to possible adulteration of certain psychedelic and dissociative drugs, particularly those taken in pill, powder, or liquid form.15
Limited research suggests that use of psychedelic drugs, such as psilocybin and LSD, does not typically lead to addiction.1,35 Researchers think that one reason may be because people commonly experience unpleasant side effects when taking these substances, including headaches and nausea, which reduces their desire to take them again.66 While short-term positive and negative mood changes are common with psychedelic and dissociative drugs, more research is needed to better understand the long-term effects these substances may have on mental health. NIDA conducts and supports research to better understand how often and to what extent people experience tolerance, withdrawal, and other substance use disorder symptoms related to the use of psychedelic and dissociative drugs. Most people who report using psychedelic and dissociative drugs do so outside of medical or research settings.1,28 While further research is also needed to better understand the health and safety impacts of typical use of these drugs, some serious adverse effects and safety issues have been identified.14,27 People who take psychedelic drugs like psilocybin may also experience short-term side effects such as raised blood pressure and heart rate, agitation, confusion, vomiting, or nausea, which may be severe and require medical attention. The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)—a reference text professionals use to diagnose substance use disorders and other psychiatric disorders—includes diagnoses of phencyclidine (PCP) use disorder and “other hallucinogen use disorder”64,65 but does not include substance use disorder diagnoses related to other specific psychedelic and dissociative drugs.
Psilocybin mushrooms fall under a broader drug category known as psychedelic and dissociative drugs, which can temporarily alter a person’s mood, thoughts, and perceptions. Preliminary research indicates that psilocybin may be helpful in treating substance use disorders, including tobacco use disorder.19,20 NIDA is funding a large, multi-site study on the effectiveness of psilocybin versus a nicotine patch, in combination with therapy, to help people stop smoking. For more information, see “What is the relationship between psychedelic and dissociative drugs and mental illness?
Together, the authors note that these factors may influence nonmedical or recreational use of psilocybin mushrooms in the U.S. Importantly, research on psychedelics as a medical treatment is done within a therapeutic structure, which includes a preparatory session with a clinician, a controlled environment and supervision while experiencing the effects of psilocybin, and follow-up sessions. These include studies on its effectiveness and safety as a treatment for substance use disorders and to help people quit smoking. NIDA is conducting and supporting preclinical (laboratory) research into psilocybin’s effects on the brain and body, and whether there are similar substances that may have the same benefits without side-effects such as hallucinations. There is evidence that psilocybin may be an effective treatment for depression and anxiety disorders.21,22 To support further research, the FDA granted Breakthrough Therapy designation for a few formulations of psilocybin being studied for safety and efficacy as a medical treatment for depression.
For more information, see “How do psychedelic and dissociative drugs work in the brain? Other drugs such as MDMA, ibogaine, and salvia work on a variety of brain functions to cause psychedelic or dissociative effects. Psychedelic drugs (also called “classic psychedelics” or “psychedelics”), including psilocybin and LSD, mainly interact with specific receptors, which are molecular structures in the brain. NIDA conducts and supports research on psychedelic and dissociative drugs to help inform policies and health decisions around their use. Some psychedelic and dissociative drugs are also synthetic (lab-made).2 People report using psychedelic and dissociative drugs for a variety of reasons, including seeking new, fun, healing, or spiritual experiences.1,3 “Research studies suggesting its effectiveness in treating mental health issues and extensive positive media coverage may lead some people to seek shrooms outside of medical contexts.
Others take very small amounts of the substance regularly, a practice called microdosing, trying to improve their mental state and productivity.12 People have been using mushrooms that contain psilocybin for thousands of years, including in religious rituals. They may have a different sense of self, feeling that they have no personal boundaries and are one with the universe—what some researchers call “oceanic self-boundlessness”.4,6 This experience can be blissful, but it may also be frightening, and cause fear or panic. Changes A person taking psilocybin may have what’s called a mystical experience, where they enter a dreamlike, euphoric state, perhaps having visions or reliving memories. Researchers think this action is responsible for much of a person’s subjective experience when they take the mushrooms.4 They also typically Psilocybin Mushrooms make people feel as if they are disconnected from their body and environment.6
Researchers are investigating psilocybin as a potential treatment for many health disorders. Microdosing means regularly taking a very small amount of a hallucinogenic substance, usually 5-10% of a typical recreational dose, low enough so that people do not experience hallucinogenic effects. For more information, see “Are psychedelic and dissociative drugs addictive?
This means adulteration of psychedelic and dissociative drugs with fentanyl and similar compounds is possible, but more research is needed to understand to what extent this occurs. Research suggests, though, that the dissociative drugs PCP41 and ketamine53 can make symptoms worse in people who have schizophrenia, and can cause short-term episodes of psychosis, in which a person experiences hallucinations and delusions, and has trouble experiencing what is real and what is not. While more research is needed, the reported incidence of serious adverse events from professionally supervised use of specific psychedelic and dissociative drugs, such as in clinical trials, is relatively low.2,10,11,26 However, many past clinical studies on these drugs have not adequately assessed or reported on adverse events.27 People report using psychedelic and dissociative drugs for a variety of reasons. See NIDA-funded projects related to psychedelic and dissociative drugs, and learn more about related clinical trials.
More recently, researchers are exploring the use of psychedelic and dissociative drugs in medical settings as treatments for substance use disorders and for other mental health disorders such as depression, anxiety, and post-traumatic stress disorder (PTSD).4,25 A small laboratory study published on psilocybin, DMT, and mescaline suggested that these psychedelic drugs are “weakly reinforcing,” indicating their use is not likely to lead to a substance use disorder.67 However, some evidence suggests people may quickly develop a tolerance to psychedelic drugs, meaning they must keep taking more of the drug to experience the same level of effects.24 This research includes efforts to better understand the health effects of psychedelic and dissociative drugs, how chemicals in—or similar to—these drugs work in the brain, and whether they may be able to treat substance use disorders and other conditions. In recent years, there has been growing research interest in the potential of psychedelic and dissociative drugs to treat medical conditions, including mental health disorders.
These altered patterns of brain activity contribute to a person’s profound change in consciousness. Psilocin activity at the 5HT2a receptor affects how the brain works and how different brain regions communicate with each other. The mushrooms have a long history of use. Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) comes from certain types of mushrooms found on nearly every continent.1 The mushrooms, which are also known as shrooms or magic mushrooms, are typically consumed dried or powdered.
Drug Enforcement Administration (DEA) lists most psychedelic and dissociative drugs on the U.S. schedule of controlled substances. Among other health effects, dissociative drugs can also alter people’s perception of reality. Information on the use of psychedelic and dissociative drugs is collected by several national surveys. The effects of psychedelic and dissociative drugs during pregnancy are not well understood, as data are limited.
Some people who take psilocybin have extreme fear, anxiety, panic, or paranoia as they experience its hallucinogenic effects, which is known as a “bad trip.”17 People may also experience side effects like agitation, confusion, vomiting or nausea, which may be severe and require medical attention.14 With more public interest and, in some areas, fewer legal restrictions on psilocybin use, exposures reported to poison control centers have increased over the past few years.15 Psilocybin is part of a group of drugs called psychedelics—or hallucinogens—that have the potential to change a person’s sense of reality, leading them to see, hear, and feel things that are not happening in real life, or to experience reality in a different way.2 People report that they microdose to lessen mental health symptoms such as depression and stress, improve productivity, and ease pain. PCP can also cause psychosis that persists for days to weeks.6,54 While it is not clear whether ketamine raises the risk of long-term psychosis, people who engage in regular recreational use of ketamine are more likely to experience delusions, even after weeks of abstinence.55 Animal studies show that long-term use of PCP or ketamine can cause brain changes resembling those seen in people with schizophrenia.56
Researchers are also investigating other drugs sometimes classified as psychedelic and dissociative drugs, such as MDMA, and the way they work in the brain. The DMN is most active during brain activity that’s related to self-awareness—such as reflecting on past events or making plans.19 This may account for why psychedelic drugs can make a person’s thoughts less self-centered and more expansive, promoting a sense of connectedness with others and the world.10 Research suggests that the most prominent psychedelic effects stem from activity in the brain’s prefrontal cortex, an area involved in mood, cognition, and perception.17,18 Psychedelic drugs also temporarily disrupt communication between different brain regions, including the regions collectively known as the default mode network (DMN).
Among people aged 12 or older in 2021, 2.6% (or about 7.4 million people) reported using hallucinogens in the past 12 months. These surveys use the terms “hallucinogen” and “hallucinogen use disorder” and data from those surveys are reported below. While more research is needed, laboratory research and a few human studies suggest that using the dissociative drug ketamine outside of a clinical setting can lead to cravings as well as symptoms of withdrawal.68 For example, salvia activates kappa opioid receptors in the brain,21 while ibogaine affects a variety of brain receptors.8 These are part of the brain’s system for transporting glutamate, another neurotransmitter. At certain doses, psychedelics may bring on vivid visions or sensations, alter a person’s sense of self, and promote feelings of insightfulness or connection.10
Research to date suggests that use of psilocybin does not typically lead to addiction.2,18 To be diagnosed with a substance use disorder, a person must meet specific diagnostic criteria for continued substance use despite negative consequences. However, poor mental health outcomes may be more likely with use outside of clinical settings. Today, some people use the mushrooms in the hopes of having a unique, interesting, enlightening, and/or spiritual experience. When a person takes psilocybin, their body converts it to another substance, psilocin.1 Psilocin attaches to and activates receptors, or binding sites, for the brain chemical serotonin, primarily the serotonin 5-hydroxytryptamine 2A (5HT2a) receptor. Now, there is a new surge of interest in discovering how psilocybin works and its potential to help treat conditions such as depression, post-traumatic stress disorder (PTSD), addiction, pain, and neurodegenerative disorders.5 Individuals are also curious to see how psilocybin might affect their way of thinking and living.
In June 2022, NIDA’s Office of Translational Initiatives and Program Innovations also announced a new program to support small businesses to develop psychedelic-based therapies for substance use disorders. While researchers debate how to describe these drugs and how specific drugs should be classified, they generally group them according to what is known about how they work in the brain. More studies are needed to better understand how psychedelic and dissociative drugs work. Many psychedelic drugs derive from plants and fungi, and some have been used for thousands of years in traditional or religious rituals. The authors note that states and regions where seizures are reported don’t necessarily reflect the intended destinations for the seized psilocybin mushrooms.
However, most people who report using psychedelic and dissociative drugs do so outside of medical or research settings for a variety of reasons, including for recreation, or based on the belief that doing so will improve well-being or allow for spiritual or self-exploration. Some people microdose psilocybin hoping that it will improve mental health issues like depression, anxiety, and obsessive-compulsive disorder (OCD). There is evidence that indigenous people in Central America used them for healing and spiritual rituals as far back as 3000 B.C.3 Scientists began studying psilocybin decades ago, along with related substances like lysergic acid diethylamide (LSD), to examine their potential to treat mental illness, including substance use disorders.2,4
People should consult their health provider before taking any drug during pregnancy. There is also the risk of misidentifying mushrooms and taking a toxic mushroom instead of one containing psilocybin.16 According to the U.S. Some people report taking magic mushrooms on their own hoping to achieve the same results, though additional research is needed to support this outcome.
While researchers debate how to describe and classify psychedelic and dissociative drugs and other drugs with similar properties, they generally group these drugs according to how they work in the brain.3 Some people use the term “hallucinogens” to refer to all or some psychedelic and dissociative drugs. Researchers are testing psilocybin’s potential to treat mental health disorders like substance use disorders, depression, anxiety, and obsessive-compulsive disorder. According to a survey published in 2021 of more than 7,000 people, some 7%—or about 500 people—reported having used psilocybin mushrooms in the past year.6 People who use them may hope to have an enjoyable, meaningful or spiritual experience, to improve their well-being, or to self-treat a medical disorder such as depression or anxiety.2,7 Some people report “microdosing” psychedelic drugs, typically LSD or psilocybin. Among other health effects, psychedelic drugs alter a person’s perception of their surroundings.
Centers for Disease Controls and Prevention (CDC), some commercial products such as candies marketed as containing psilocybin have also been found to contain toxic chemicals and have caused severe illness. Psilocybin typically raises blood pressure and heart rate, which may be dangerous for people with heart conditions. People may do things that put themselves or others at risk of physical harm after taking mushrooms in an unsupervised environment—driving dangerously or walking in traffic, for example—as they may be less aware of their physical surroundings13 and have an impairment in their ability to think clearly. Psilocybin can cause many effects, some of them unpleasant. Magic mushrooms typically cause shifts in how a person perceives reality. Psilocybin has a wide range of potential effects.
Substance use disorders are defined in part by continued use of substances despite negative consequences. In 2022, nearly 49 million people in the United States had at least one substance use disorder. The authors also note that it is unknown to what extent psilocybin mushrooms were seized in “wet” or “dry” form, which can significantly impact the recorded weight of each seizure and prevents weight measures from being translated into possible doses.
There is some evidence that psychedelic drugs might bring about or trigger schizophrenia-like illness in people with predisposing factors, but little evidence that they cause long-term psychiatric problems for most people. Some psychedelic drugs are derived from plants and fungi that have a long history of use in many different cultures around the world.23 Aztec shamans used psilocybin in healing rituals, and some Native American tribes used peyote as long ago as 5,700 B.C. Individuals also report using these drugs in the hopes of improving their mental health or well-being or easing pain or stress, but more research is needed to determine their effectiveness for these purposes.1,3,22 NIDA conducts and supports research on psychedelic and dissociative drugs to help inform health decisions and policies related to their use.
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